A dream came true for Regine Sta. Maria when she debuted as a news anchor for the Royale-Metro Broadcasting Network (RMBN) evening news. After the newscast, she received a bouquet of flowers and a phone call from someone who calls himself her Number One Fan. His message: make him number one or else, someone will die. The next day, without receiving a call from him, she dismissed it as a mere prank. After a week, the police found her journalism professor, Prof. Jose Luis Anacleto III, dead. She realized that Number One Fan had made good of his threat. With only the tune of Twinkle, Twinkle, Little Star as her clue, Regine had to figure out who would be Number One Fan’s next victim as journalists around her start to die one by one.